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. 2019 Feb 26;10:299. doi: 10.3389/fimmu.2019.00299

Figure 6.

Figure 6

Interindividual sharing across all six donors of TCRβ amino acid clonotypes. (A) The number of individuals in which a TCRβ amino acid clonotype was observed, and the proportions of unique TCRβ amino acid clonotypes (Left panel) in the four T cell subsets repertoires of Donors 1–6 that were observed in one, two, three, four, five, or all six individuals. The same analysis was performed across the total TCRβ repertoires (including the size of each clonotype) (Right panel). (B) The TCRβ amino acid clonotypes which shared by ≥2 of 6 donors (2+) had a significantly shorter CDR3 length (Left panel) and a significantly larger size (Right panel) compared with those that presented only in a donor (Private), which observed in all the four T cell subsets (4RA, 4RO, 8RA, and 8RO). The statistics of CDR3 length and clonotype size were based on unpaired t-test and Mann-Whitney U test, respectively. *P < 0.05, **P < 0.01, ****P < 0.0001 (two-tailed).