. 2019 Feb 26;10:292. doi: 10.3389/fimmu.2019.00292

Table 1.

Binding activities of human FcγR to IgG isotypes and resulting effector functions.

FcγR	Variants	IgG1		IgG2		IgG4
FcγR	Variants	Affinity^a	Effector functions	Affinity	Effector functions	Affinity	Effector functions
I	NA	High	ADCP	None	None	High	ADCP, Cytokine release
IIa	H₁₃₁	Medium	ADCP	Medium	Myeloid cell-induced ADCC^b	Low	Receptorclustering^c
IIa	R₁₃₁	Low	ADCP	Low	Myeloid cell-induced ADCC^b	Low	Receptorclustering^c
IIb	I₂₃₂^d	Low	Clearance of IC, Immuno-suppression	None	None	Low	Clearance of IC, Immuno-suppression
IIb	T₂₃₂^d	Low	Clearance of IC, Immuno-suppression	None	None	Low	Clearance of IC, Immuno-suppression
IIIa	V₁₅₈	Medium	ADCC	Low	None	Low	None
IIIa	F₁₅₈	Low	ADCC	None	None	None	None

Affinity values are based on IC binding to FcγR, adapted from Bruhns et al. (13).

Based on Arce Vargas et al. (15).

Based on Oberst et al. (16).

The T₂₃₂ variant is less potent in inhibitory activity than the I₂₃₂ variant (17). However, the I₂₃₂T mutation leads to significantly better phagocytosis (18).