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. 2019 Feb 26;10:81. doi: 10.3389/fpsyt.2019.00081

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Copyright © 2019 Georgiou, Zanos, Jenne and Gould.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of stress in male and female Esr2^+/− and Esr2^−/− mice. No difference was observed between the different genotypes following inescapable shock training in male mice in the (A) escape latency and (B,C) escape failures. (D) Male Esr2^−/− mice decreased their sucrose preference following stress compared with their baseline and Esr2^+/− mice. Female Esr2^−/− mice demonstrated decreased (E) escape latency. Although no statistically significant difference was observed in the (F) escape failures timeline, (G) female Esr2^−/− mice had lower total escape failures compared with Esr2^+/− mice. (H) No difference was observed in the pre- and post-stress sucrose preference. ^*p < 0.05, ^***p < 0.001; n = 13, 11 for (A–D), n = 9, 8 for (E–H).