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. 2019 Feb 26;10:306. doi: 10.3389/fimmu.2019.00306

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Copyright © 2019 Liu, Qiu, Wang, Zeng, Liu, Chen, Liang, Zhang, Han and Dai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD8⁺CD122⁺PD-1⁺ Tregs synergizes with costimulatory blockade of CD40/CD154, but not B7/CD28, to suppress mRNA expression of proinflammatory cytokines in skin allografts. mRNA expression of IFN-γ, TNF-α, and IL-6 in skin allografts was measured using RT-PCR assays 2 weeks after skin transplantation and treatment with CD8⁺CD122⁺PD-1⁺ Tregs, MR1, or CTLA4-Ig. Data are presented as mean ± SD. One representative of three separate experiments is shown (*P < 0.05).