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. 2019 Feb 26;10:308. doi: 10.3389/fimmu.2019.00308

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Copyright © 2019 Schwager and Detmar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of lymphatic vessel stimulation or inhibition on skin inflammation. Inflamed skin presents with epidermal thickening, edema and infiltration by inflammatory leukocytes (e.g., CD8-positive cells or macrophages and granulocytes). Stimulation of the lymphatic vasculature alleviates inflammation, reducing edema, epidermal thickening and inflammatory infiltration while improving lymphatic drainage, thus lowering the numbers of inflammatory cells in the inflamed skin. Inhibition of the lymphatic vasculature aggravates inflammation and reduces lymphatic clearance.