Table 1.

Inducers that inhibit GPX4.

Inducers	Drugs	Mechanisms	Reference
Erastin	Sorafenib (an anti-cancer drug)	Depletion of GSH	Dixon et al., 2012;
Erastin derivatives	sulfasalazine (an anti-inflammatory drug)	Inactivation of GPX4	Friedmann Angeli et al., 2014; Lachaier et al., 2014;
Glutamate	Artesunate(an anti-malaria drug)		Eling et al., 2015; Roh et al., 2017
BSO
RSL3	Altretamine (an anti-cancer drug)	Directly bind to GPX4 Inactivate GPX4	Woo et al., 2015; Yang et al., 2016
FIN56		Promote the degradation of GPX4	Shimada et al., 2016b
		Decrease the abundance of GPX4
FINO2		Indirectly inactivate GPX4 Directly oxidize iron and lipid	Abrams et al., 2016; Gaschler et al., 2018a