Table 1.
Inducers | Drugs | Mechanisms | Reference |
---|---|---|---|
Erastin | Sorafenib (an anti-cancer drug) | Depletion of GSH | Dixon et al., 2012; |
Erastin derivatives | sulfasalazine (an anti-inflammatory drug) | Inactivation of GPX4 | Friedmann Angeli et al., 2014; Lachaier et al., 2014; |
Glutamate | Artesunate(an anti-malaria drug) | Eling et al., 2015; Roh et al., 2017 | |
BSO | |||
RSL3 | Altretamine (an anti-cancer drug) | Directly bind to GPX4 Inactivate GPX4 | Woo et al., 2015; Yang et al., 2016 |
FIN56 | Promote the degradation of GPX4 | Shimada et al., 2016b | |
Decrease the abundance of GPX4 | |||
FINO2 | Indirectly inactivate GPX4 Directly oxidize iron and lipid | Abrams et al., 2016; Gaschler et al., 2018a |