Table 2.
Diagnostic Performance of Immunoglobulin A Responses as Assessed by Area Under the Receiver Operating Characteristic Curve, Sensitivity, and Specificity in Out-of-Sample Validation
Antigen(s) | AUC (95% CI) | Specificity (at 90% Sensitivity), % | Sensitivity (at 90% Specificity), % |
---|---|---|---|
HlyE | 0.93 (.88–.98) | 87 | 78 |
MP | 0.83 (.76–.90) | 48 | 61 |
LPS | 0.92 (.87–.97) | 77 | 68 |
HlyE and LPS | 0.95 (.90–1.00) | 92 | 91 |
HlyE, LPS, and MP | 0.95 (.90–.99) | 90 | 87 |
Abbreviations: AUC: area under the receiver operating characteristic curve; CI, confidence interval; HlyE, hemolysin E; LPS, lipopolysaccharide; MP, membrane preparation.