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A schematic model of the mechanism by which HSV-2 ICP27 inhibits IFN-β production. HSV-2 dsRNA is detected by RIG-I, which recruits MAVS and downstream TBK1 and IKK-ε complex. HSV-2 ICP27 interacts with IRF3 and interferes with IRF3 activation by blocking IRF3 phosphorylation and nuclear translocation, thereby inhibiting the production of IFN-β and ISGs.
