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Schematic representation of the mechanism by which the matriptase-MSP-RON signaling axis modulates pancreatic cancer progression. Matriptase mediates maturation and activation of MSP, which in turn stimulates RON-modulated signaling events. It is conceivable that Matriptase and MSP may also contribute to remodeling of the tumor microenvironment, through regulating the functions of the stellate cell, the macrophage, or other immune cells.
