Table 2.
The validation of the top 10 predicted asthma-related microbes after implementing MDLPHMDA based on the confirmed microbe-disease associations from HMDAD.
| Disease | Microbe | Score | Evidence |
|---|---|---|---|
| Asthma | Firmicutes | 0.035113958 | PMID:23265859 |
| Asthma | Clostridium difficile | 0.026401159 | PMID:21872915 |
| Asthma | Clostridium coccoides | 0.023247917 | PMID:21477358 |
| Asthma | Staphylococcus aureus | 0.022891159 | PMID:25533526 |
| Asthma | Actinobacteria | 0.022703105 | PMID:23265859 |
| Asthma | Lachnospiraceae | 0.022512904 | PMID: 27433177 |
| Asthma | Lactobacillus | 0.022019371 | PMID:20592920 |
| Asthma | Enterobacteriaceae | 0.018834777 | PMID:21639872 |
| Asthma | Veillonella | 0.018243753 | PMID: 26424567 |
| Asthma | Bacteroides | 0.017354957 | PMID: 18822123 |
As a result, all of the top 10 predicted microbes were confirmed by literatures.