Table 4.
The validation of the top 10 predicted liver cirrhosis-associated microbes after implementing MDLPHMDA by removing liver cirrhosis-related associations from the dataset of known microbe-disease associations.
| Disease name | Microbe name | Score | Evidence |
|---|---|---|---|
| Liver cirrhosis | Proteobacteria | 0.037652208 | HMDAD |
| Liver cirrhosis | Bacteroidetes | 0.033708121 | HMDAD |
| Liver cirrhosis | Firmicutes | 0.033302216 | PMID:21574172 |
| Liver cirrhosis | Prevotella | 0.028842704 | HMDAD |
| Liver cirrhosis | Helicobacter pylori | 0.021108828 | PMID:9365129 |
| Liver cirrhosis | Clostridium difficile | 0.020872569 | PMID:26440041 |
| Liver cirrhosis | Actinobacteria | 0.020204542 | PMID:22326468 |
| Liver cirrhosis | Clostridium coccoides | 0.018391455 | Unconfirmed |
| Liver cirrhosis | Staphylococcus aureus | 0.01835198 | PMID:22833245 |
| Liver cirrhosis | Lactobacillus | 0.016449739 | HMDAD |
As a result, 9 out of the top 10 predicted microbes were confirmed by HMDAD and literatures.