Table 5.
The validation of the top 10 predicted type 1 diabetes-related microbes after implementing MDLPHMDA by removing type 1 diabetes-related associations from the dataset of known microbe-disease associations.
| Disease name | Microbe name | Score | Evidence |
|---|---|---|---|
| Type 1 diabetes | Proteobacteria | 0.035314225 | HMDAD |
| Type 1 diabetes | Bacteroidetes | 0.030725459 | HMDAD |
| Type 1 diabetes | Firmicutes | 0.02813792 | HMDAD |
| Type 1 diabetes | Prevotella | 0.026244828 | HMDAD |
| Type 1 diabetes | Clostridium difficile | 0.021633674 | Unconfirmed |
| Type 1 diabetes | Helicobacter pylori | 0.021284419 | PMID:27497772 |
| Type 1 diabetes | Clostridium coccoides | 0.019300705 | Unconfirmed |
| Type 1 diabetes | Staphylococcus aureus | 0.017744364 | PMID:19411183 |
| Type 1 diabetes | Lactobacillus | 0.016082255 | HMDAD |
| Type 1 diabetes | Actinobacteria | 0.015923043 | HMDAD |
As a result, 8 out of the top 10 predicted microbes were confirmed by HMDAD and literatures.