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. 2019 Jan 9;60(3):636–647. doi: 10.1194/jlr.M091736

Fig. 5.

Fig. 5.

Lipids extracted from metacyclic promastigotes promote the polarization of macrophages into a proresolving M2 phenotype. A: mRNA expression of markers of M1 and M2 polarization quantified in BMDMs after treatment with lipid metabolites from procyclic and metacyclic promastigotes. Data shown are means of fold changes ± SEMs compared with the undifferentiated monocyte (M0) from three independent experiments conducted in triplicate (n = 3). **P < 0.01 significantly different from the procyclic lipid extract group. B: Gene expression of M1 and M2 markers in BMDMs after treatment with lipid extracts from procyclic and metacyclic promastigotes and/or IFN-γ. Data shown are means of fold changes ± SEMs compared with the undifferentiated monocyte (M0) from three independent experiments conducted in triplicate (n = 3). *P < 0.05 and **P < 0.01 significantly different from the IFN-γ group. iNOS, inducible nitric oxide synthase; IRF5, IFN regulatory factor 5; Socs3, suppressor of cytokine signaling 3.