TABLE 2.

PUFA metabolite concentration (nmol/1 × 10⁸ parasites) in L. infantum at the procyclic or metacyclic promastigote stage

Metabolites	Procyclic	Metacyclic	P
9,10-DiHOME	17.68 ± 0.48	21.21 ± 0.69	0.0048
9,10-DiHODE	10.92 ± 0.21	12.01 ± 0.32	0.0298
15,16-DiHODE	5.83 ± 0.16	5.957 ± 0.12	0.8092
9-HODE	396.80 ± 34.93	249.91 ± 34.33	0.0298
10-HODE	14.24 ± 0.92	15.08 ± 0.75	0.4649
12-HODE	17.44 ± 0.81	19.32 ± 0.27	0.0298
13-HODE	962.11 ± 66.13	1,065.00 ± 67.89	0.3743
15-HODE	8.11 ± 0.10	7.41 ± 0.41	0.2198
5-HETE	26.29 ± 5.73	26.69 ± 4.25	1.0000
8-HETE	5.26 ± 0.29	13.68 ± 3.60	0.0048
11-HETE	3.87 ± 0.38	9.70 ± 0.90	0.0048
12-HETE	12.61 ± 3.94	12.15 ± 3.27	1.0000
15-HETE	43.57 ± 7.46	50.98 ± 1.15	0.7163
18-HETE	110.30 ± 7.48	112.01 ± 3.34	0.8092
5(S)-HETrE	0.970 ± 0.09	1.347 ± 0.13	0.1262
8(S)-HETrE	38.12 ± 6.69	44.35 ± 8.47	0.6879
12(S)-HETrE	12.25 ± 0.98	14.17 ± 0.93	0.1474
15(S)-HETrE	31.26 ± 2.36	39.37 ± 1.83	0.0766
8(9)-EpETrE	17.20 ± 2.07	2.91 ± 2.91	0.0247
4-HDoHE	146.10 ± 2.56	218.80 ± 17.02	0.0048
7-HDoHE	32.44 ± 2.44	37.94 ± 1.83	0.1262
8-HDoHE	114.80 ± 16.21	123.70 ± 10.91	0.1269
10-HDoHE	48.33 ± 3.24	47.18 ± 12.96	0.3760
11-HDoHE	63.44 ± 11.77	90.39 ± 8.89	0.1262
13-HDoHE	64.82 ± 3.81	64.05 ± 3.99	1.0000
14-HDoHE	112.10 ± 6.27	177.00 ± 18.81	0.0126
16-HDoHE	59.07 ± 3.22	69.35 ± 3.96	0.1262
17-HDoHE	129.1 ± 13.84	268.5 ± 39.05	0.0022
20-HDoHE	248.91 ± 24.76	327.50 ± 22.75	0.0431
7(8)-EpDPE	38.82 ± 3.271	46.52 ± 2.80	0.0646
10(11)-EpDPE	18.27 ± 1.89	24.83 ± 3.67	0.2403
13(14)-EpDPE	20.62 ± 2.43	19.75 ± 2.29	0.9360
16(17)-EpDPE	15.30 ± 2.08	19.19 ± 1.67	0.0646
19(20)-EpDPE	56.28 ± 5.09	69.91 ± 1.36	0.0301
10,11-DiHDPE	3.31 ± 0.29	3.64 ± 0.23	0.2598
13,14-DiHDPE	3.56 ± 0.30	3.99 ± 0.20	0.4616
16,17-DiHDPE	1.98 ± 0.63	2.22 ± 0.73	0.9348

DiHOME, dihydroxyoctadecenoic acid; HETrE, dihydroxyeicosatrienoic acid.