Fig. 1.

L-Sort1 KO mice fed a WD showed reduced weight gain. A: Illustration of conditional Sort1 KO strategy. B. Male 6-week-old L-Sort1 KO (L-KO) mice and WT mice were fed chow or WD for 12 weeks. Body weight was measured weekly (n = 10–12). C: Weight gain over the 12 week feeding period (n = 10–12). D, E: Representative Western blotting of Sort1 protein in liver and white adipose tissue. Relative Sort1 band intensity after normalization to actin band intensity (n = 10). Results wereare expressed as mean ± SEM. *P < 0.05 versus WT + chow. #P < 0.05 versus WT + WD.