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WD-fed L-Sort1 KO mice showed lowered plasma cholesterol and hepatic bile acid levels. Male 6-week-old L-Sort1 KO (L-KO) mice and WT mice were fed chow or WD for 12 weeks. A: Plasma cholesterol. B: Plasma TG. C: Tissue bile acid (BA) content and total bile acid pool size. D: Hepatic mRNA expression. Results are expressed as mean ± SEM (n = 10–12). *P < 0.05 versus WT + chow. #P < 0.05 versus WT + WD.
