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LysM-Sort1 KO mice did not show altered plasma cholesterol or bile acid pool. Male 12-week-old LysM-Sort1 KO (LysM-KO) mice and WT mice were fed chow or WD for 12 weeks. A, B: Plasma cholesterol and TG concentration. C: Total organ bile acid (BA) content and bile acid pool. D: Liver bile acid concentration. The P values shown are comparisons to the WT + Chow group. E: Relative liver CYP7A1 mRNA expression. Results are expressed as mean ± SEM (n = 5–10). *P < 0.05 versus WT + chow.
