Fig. 8.

AF38469 treatment decreased plasma cholesterol and hepatic VLDL secretion in WD-fed mice. A, B, D–F: Male 12-week-old C57BL/6J mice were fed either WD or WD supplemented with AF38469 (AF) for 8 weeks. Plasma cholesterol (A), TG (B), gallbladder (GB) total cholesterol content (D), tissue total bile acid content and bile acid pool (E), and hepatic mRNA expression (E) are shown. C: Male 12-week-old C57BL/6J mice were fed either WD or WD supplemented with AF38469 (AF) for 2 weeks. A VLDL secretion assay was performed as described in the Materials and Methods. Results are expressed as mean ± SEM (n = 5). *P < 0.05 versus WD-fed mice.