TABLE 1.
Baseline demographic and clinical characteristics according to serum lipid trajectories defined on the basis of GBTM
| Variables | Total (n = 4,647) | T-CHO | TG | LDL-C | HDL-C | ||||
| Trajectory 1: Normal (n = 3,235) | Trajectory 2: High (n = 1,412) | Trajectory 1: Normal (n = 4,045) | Trajectory 2: High (n = 602) | Trajectory 1: Normal-Low (n = 1,928) | Trajectory 2: Normal (n = 918) | Trajectory 1: Normal (n = 1,703) | Trajectory 2: Normal-High (n = 415) | ||
| Age at entry (years) | 67.0 (56.8, 75.6) | 69.2 (59.4, 76.9) | 61.2 (51.4, 71.3) | 67.8 (57.5, 76.0) | 60.4 (51.5, 71.4) | 68.0 (59.0, 76.1) | 61.6 (51.5, 72.3) | 67.5 (58.3, 75.6) | 67.7 (56.8, 75.8) |
| Female | 1,922 (41.4) | 1,200 (37.1) | 722 (51.1) | 1,665 (41.2) | 257 (42.7) | 744 (38.59) | 401 (43.68) | 607 (35.64) | 232 (55.9) |
| BMI (kg/m2) | 24.4 (22.1, 27.2) | 24.4 (22.1, 27.2) | 24.5 (22.1, 27.2) | 24.2 (21.9, 27.0) | 25.9 (23.8, 28.4) | 24.8 (22.6, 27.5) | 24.7 (22.6, 27.2) | 25.3 (23.2, 27.9) | 23.5 (21.3, 26.4) |
| Initial CKD stage | |||||||||
| 1 | 199 (4.3) | 106 (3.3) | 93 (6.6) | 171 (4.2) | 28 (4.7) | 85 (4.42) | 82 (8.95) | 85 (5) | 35 (8.43) |
| 2 | 376 (8.1) | 230 (7.1) | 146 (10.4) | 322 (8.0) | 54 (9.0) | 184 (9.56) | 131 (14.3) | 198 (11.65) | 41 (9.88) |
| 3 | 2,139 (46.1) | 1,510 (46.7) | 629 (44.7) | 1,856 (46.0) | 283 (47.1) | 1,032 (53.61) | 488 (53.28) | 842 (49.53) | 216 (52.05) |
| 4 | 1,226 (26.4) | 869 (26.9) | 357 (25.4) | 1,064 (26.4) | 162 (27.0) | 463 (24.05) | 163 (17.79) | 422 (24.82) | 100 (24.1) |
| 5 | 698 (15.1) | 516 (16.0) | 182 (12.9) | 624 (15.5) | 74 (12.3) | 161 (8.36) | 52 (5.68) | 153 (9) | 23 (5.54) |
| Diabetes | 1,896 (40.8) | 1,389 (42.9) | 507 (35.9) | 1,582 (39.1) | 314 (52.2) | 1,069 (55.45) | 344 (37.47) | 1,093 (64.18) | 201 (48.43) |
| Hypertension | 2,755 (59.3) | 1,939 (59.9) | 816 (57.8) | 2,349 (58.1) | 406 (67.4) | 1,247 (64.68) | 518 (56.43) | 1,176 (69.05) | 253 (60.96) |
| CVD | 1,777 (38.2) | 1,402 (43.3) | 375 (26.6) | 1,561 (38.6) | 216 (35.9) | 906 (46.99) | 267 (29.08) | 841 (49.38) | 155 (37.35) |
| Baseline biochemical profiles | |||||||||
| T-CHO (mg/dl) | 186 (161, 214) | 173 (152, 196) | 218 (196, 249) | 184 (159, 211) | 203 (176, 234) | 176 (154, 202) | 208 (187, 238) | 183 (158, 210) | 192 (168, 223) |
| TG (mg/dl) | 138 (97, 203) | 128 (91, 187) | 162 (117, 242) | 127 (92, 175) | 284 (216, 386) | 145 (101, 215) | 141 (105, 195) | 155 (114, 230) | 113 (79, 152) |
| LDL-C (mg/dl) | 105 (84, 127) | 99 (79, 119) | 121 (101, 146) | 105 (85, 128) | 98 (76, 120) | 97 (78, 114) | 126 (111, 145) | 102 (82, 124) | 103 (81, 129) |
| HDL-C (mg/dl) | 40.2 (34.2, 48.4) | 39.1 (33.2, 46.3) | 43.6 (37.2, 53.0) | 40.9 (34.5, 49.4) | 37.5 (32.3, 43.1) | 39.4 (33.8, 47.1) | 42.7 (37.1, 50.9) | 37.9 (32.9, 43.3) | 55.8 (48.9, 63.7) |
| eGFR (ml/min/1.73 m2) | 34.5 (20.2, 50.2) | 33.5 (19.5, 49.4) | 36.8 (22.2, 52.7) | 34.3 (20.1, 49.9) | 35.3 (21.5, 52.1) | 39.6 (25.2, 53.3) | 46.3 (31.2, 58.9) | 38.4 (24.7, 53.8) | 41.5 (27.0, 55.0) |
| Hemoglobin (g/dl) | 11.4 (9.8, 13.1) | 11.3 (9.7, 13.0) | 11.5 (10.1, 13.4) | 11.3 (9.8, 13.1) | 11.9 (10.1, 13.8) | 11.7 (10.1, 13.3) | 12.3 (10.7, 13.8) | 11.9 (10.3, 13.5) | 11.7 (10.1, 13.0) |
| SUA (mg/dl) | 7.30 (6.20, 8.50) | 7.30 (6.19, 8.50) | 7.35 (6.30, 8.42) | 7.30 (6.20, 8.40) | 7.60 (6.46, 8.90) | 7.20 (6.10, 8.40) | 7.30 (6.20, 8.40) | 7.34 (6.20, 8.50) | 7.00 (5.90, 8.04) |
| Serum creatinine (mg/dl) | 1.79 (1.33, 2.77) | 1.82 (1.36, 2.86) | 1.70 (1.25, 2.58) | 1.80 (1.34, 2.80) | 1.74 (1.29, 2.60) | 1.60 (1.25, 2.27) | 1.45 (1.09, 1.93) | 1.63 (1.25, 2.36) | 1.51 (1.10, 2.04) |
| Serum albumin (g/dl) | 4.00 (3.60, 4.30) | 4.00 (3.70, 4.30) | 4.00 (3.40, 4.30) | 4.00 (3.60, 4.30) | 4.15 (3.72, 4.43) | 4.10 (3.70, 4.35) | 4.05 (3.60, 4.30) | 4.03 (3.68, 4.30) | 4.00 (3.53, 4.30) |
| TG/HDL-C ratio | 3.60 (2.26, 6.05) | 3.50 (2.20, 5.68) | 4.06 (2.53, 6.99) | 3.22 (2.09, 4.90) | 7.73 (5.62, 10.79) | 3.73 (2.30, 6.14) | 3.38 (2.36, 5.46) | 4.20 (2.76, 6.73) | 1.96 (1.37, 3.13) |
| Urine PCR (mg/g) | 762 (209, 2119) | 626 (192, 1,727) | 1,149 (293, 3,331) | 731 (200, 2,004) | 1,129 (306, 2,871) | 477 (164, 1,584) | 662 (177, 2,225) | 643 (200, 2,192) | 545 (155, 2,010) |
The bold values denote significant difference between the groups at P < 0.05.