TABLE 3.
HRs (95% CIs) of all-cause mortality by baseline level and trajectory group of each lipid component
| Baseline Serum Lipid and Longitudinal Trajectory | Number | Cases | Person-Years | Incidencea | Crude HR (95% CI) | Model 1 [Adjusted HR (95% CI)] | Model 2 [Adjusted HR (95% CI)] | Model 3 [Adjusted HR (95% CI)] | Model 4 [Adjusted HR (95% CI)] | Model 5 [Adjusted HR (95% CI)] |
| All-cause mortality | ||||||||||
| T-CHO | ||||||||||
| Baseline (per 20 mg/dl increase) | 4,647 | 404 | 15,712.6 | 25.7 | 0.86 (0.82, 0.90) | 0.92 (0.87, 0.97) | 0.93 (0.88, 0.98) | 0.96 (0.90, 1.01) | 0.97 (0.92, 1.02) | 0.96 (0.91, 1.01) |
| P | <0.001 | 0.001 | 0.009 | 0.097 | 0.222 | 0.141 | ||||
| Trajectory: normal (Ref) | 3,235 | 320 | 10,537.4 | 30.4 | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
| Trajectory: high | 1,412 | 84 | 5,175.2 | 16.2 | 0.51 (0.40, 0.64) | 0.73 (0.57, 0.94) | 0.79 (0.62, 1.01) | 0.85 (0.66, 1.09) | 0.87 (0.68, 1.11) | 0.85 (0.66, 1.10) |
| P | <0.001 | 0.013 | 0.064 | 0.203 | 0.262 | 0.212 | ||||
| TG | ||||||||||
| Baseline (per 20 mg/dl increase) | 4,647 | 404 | 15,712.6 | 25.7 | 0.97 (0.95, 1.00) | 1.00 (0.98, 1.02) | 0.99 (0.97, 1.01) | 0.99 (0.96, 1.01) | 0.98 (0.96, 1.01) | 0.98 (0.96, 1.01) |
| P | 0.016 | 0.836 | 0.371 | 0.268 | 0.191 | 0.163 | ||||
| Trajectory: normal (Ref) | 4,045 | 360 | 13,689.6 | 26.3 | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
| Trajectory: high | 602 | 44 | 2,023.0 | 21.8 | 0.83 (0.61, 1.13) | 1.22 (0.89, 1.68) | 1.08 (0.78, 1.49) | 0.99 (0.71, 1.38) | 0.95 (0.68, 1.33) | 0.95 (0.68, 1.32) |
| P | 0.239 | 0.221 | 0.633 | 0.948 | 0.768 | 0.748 | ||||
| LDL-C | ||||||||||
| Baseline (per 10 mg/dl increase) | 2,846 | 176 | 10,347.9 | 17.0 | 0.92 (0.88, 0.97) | 0.95 (0.90, 0.99) | 0.96 (0.92, 1.01) | 0.96 (0.91, 1.01) | 0.97 (0.92, 1.02) | 0.97 (0.92, 1.02) |
| P | <0.001 | 0.029 | 0.134 | 0.139 | 0.206 | 0.175 | ||||
| Trajectory: normal-low (Ref) | 1,928 | 135 | 6,573.7 | 20.5 | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
| Trajectory: normal | 918 | 41 | 3,774.1 | 10.9 | 0.48 (0.34, 0.68) | 0.66 (0.46, 0.94) | 0.79 (0.55, 1.13) | 0.84 (0.58, 1.21) | 0.90 (0.62, 1.30) | 0.89 (0.62, 1.29) |
| P | <0.001 | 0.021 | 0.200 | 0.356 | 0.570 | 0.540 | ||||
| HDL-C | ||||||||||
| Baseline (per 10 mg/dl increase) | 2,118 | 173 | 7,619.6 | 22.7 | 1.00 (0.88, 1.14) | 1.02 (0.90, 1.17) | 1.10 (0.96, 1.26) | 1.14 (1.00, 1.29) | 1.20 (1.06, 1.36) | 1.20 (1.06, 1.36) |
| P | 0.980 | 0.734 | 0.153 | 0.054 | 0.004 | 0.005 | ||||
| Trajectory: normal-high (Ref) | 415 | 31 | 1,576.2 | 19.7 | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
| Trajectory: normal | 1,703 | 142 | 6,043.4 | 23.5 | 1.24 (0.84, 1.83) | 1.11 (0.74, 1.65) | 0.99 (0.66, 1.49) | 0.90 (0.59, 1.35) | 0.86 (0.57, 1.29) | 0.85 (0.56, 1.29) |
| P | 0.277 | 0.617 | 0.964 | 0.605 | 0.464 | 0.452 |
Bold values denote significant difference between the groups at P < 0.05. Model 1: adjusted for age at entry, gender, BMI, smoking, alcohol, and education; Model 2: further adjusted for diabetes, hypertension, CVD, and primary etiologies of CKD; Model 3: further adjusted for baseline medications listed in Table 1; Model 4: further adjusted for baseline eGFR and eGFR trajectories; Model 5: further adjusted for baseline PCR.
a
Incidence = number of incident dialysis cases/person-years × 1,000.