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. 2019 Jan 4;60(3):528–538. doi: 10.1194/jlr.M089722

Fig. 5.

Fig. 5.

Changes in gene expression of triglyceride synthesis pathway enzymes and PPARα target genes and PPARα activity during prolonged fasting in mice following Mogat1 ASO treatment. Male C57BL/6J mice were injected (intraperitoneally) twice weekly with ASOs targeted against Mogat1 or scramble control (25 mg/kg) for 3 weeks prior to fasting (24 h) and liver harvest. A: Fasting mice receiving Mogat1 ASO had significantly lower hepatic gene expression of glycerolipid enzymes compared with control ASO-treated mice. B: Hepatic PPARα target gene expression. C: Gene expression of transcriptional regulators. D: Nuclear PPARα activity in fasted mice. Data shown as mean ± SE; *P < 0.05 where indicated; n = 6–10.