TABLE 3.
- Plasma parameters in the WY-14643 study
| Control ASO (Fed) Vehicle | Control ASO (Fasted) Vehicle | Mogat1 ASO (Fasted) Vehicle | Control ASO (Fasted) WY-14643 | Mogat1 ASO (Fasted) WY-14643 | |
| Triglycerides (mg/dl) | 82.57 ± 6.7 | 167.4 ± 31.8 | 84.02 ± 7.1a | 119.1 ± 15.8 | 111.9 ± 9.8 |
| NEFA (mmol/l) | 0.38 ± 0.08 | 1.04 ± 0.1 | 0.73 ± 0.04 | 0.97 ± 0.11 | 1.08 ± 0.31 |
| Ketones (μmol/l) | 132.4 ± 9.3 | 1,276.4 ± 69.1 | 891.7 ± 144.4* | 1023.5 ± 132.6 | 988.6 ± 76.1 |
| Blood glucose (mg/dl) | 157 ± 4.5 | 79.4 ± 3.3 | 84.4 ± 3.0 | 89.2 ± 3.6 | 82.6 ± 1.8 |
Plasma was collected after oral gavage of vehicle or WY-14643 (100 mg/kg) and fasting (18 h) or fed. Data are shown as mean ± SE; fed controls shown for reference (n = 5).
a
P < 0.05 versus Control ASO (fasted) vehicle-treated mice.