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. 2019 Jan 17;60(3):506–515. doi: 10.1194/jlr.M088443

Fig. 4.

Fig. 4.

The 22(R)-OHC is unable to stimulate cholesterol efflux in S1P3-deficient macrophages. A: 3H-cholesterol efflux to ApoA-I was measured in S1P1 KO and WT macrophages, incubated with 6.25 μM 22(R)-OHC for 18 h. Individual points represent individual mice. Data are presented as mean ± SEM (n = 4 per group). Statistical analysis was performed using two-way ANOVA followed by Bonferroni test. * P < 0.05. B: 3H-cholesterol efflux to ApoA-I was measured in S1P2 KO and WT macrophages treated as in A. Individual points represent individual mice. Data are presented as mean ± SEM (n = 4 or 5 per group). Statistical analysis was performed using two-way ANOVA followed by Bonferroni test. * P < 0.05. C: 3H-cholesterol efflux to ApoA-I was measured in S1P3 KO and WT macrophages, incubated as in A. Individual points represent individual mice. Data are presented as mean ± SEM (n = 9 or 10 per group). Statistical analysis was performed using two-way ANOVA followed by Bonferroni test. *** P < 0.001. n.s., not significant.