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Gene trap disruption of the Sgpl1 gene causes S1P lyase deficiency. A: Sphingolipid metabolic pathway and linkage to triacylglycerol and PtdE synthesis. B: Appearance and life span of Sgpl1−/−, Sgpl1+/−, and Sgpl1+/+ mice. Photo shows knockout mouse on the left and wild type mouse on the right. Reproduced with permission from ref. 17.
