TABLE 1.

Functional characteristics of GABA_A receptor mutants

Receptor	GABA EC50 [95% CI (n)]	GABA Efficacy ± S.D.	IPTX/IGABAmax ± S.D.
	µM
α1β3γ2L	59 [53–66 (n = 3)]	0.88 ± 0.024 (n = 5)	<0.001 (n = 3)
M2-15′
α1S270Iβ3γ2L	2.3 [2.1–2.6 (n = 3)]	0.78 ± 0.054 (n = 6)	0.020 ± 0.0072 (n = 3)
α1β3N265Mγ2L	141 [128–156 (n = 3)]	0.75 ± 0.024 (n = 4)	<0.001 (n = 3)
α1β3γ2LS280W	29 [24–35 (n = 4)]	0.70 ± 0.053 (n = 3)	0.015 ± 0.0043 (n = 3)
M3-36′
α1A291Wβ3γ2L	0.37 [0.27–0.52 (n = 3)]	0.99 ± 0.036 (n = 6)	0.10 ± 0.014 (n = 3)
α1β3M286Wγ2L	5.9 [4.5–7.7 (n = 4)]	0.96 ± 0.032 (n = 5)	0.061 ± 0.034 (n = 5)
α1β3γ2LS301W	43 [32–58 (n = 3)]	0.84 ± 0.054 (n = 7)	0.078 ± 0.0088 (n = 3)

CI, confidence interval.