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. 2019 Jan 21;20(3):e46821. doi: 10.15252/embr.201846821

Figure EV1. KMT2C promoter methylation in human cancers.

Figure EV1

  1. Schematic of the upstream promoter region of the KMT2C locus indicating the position and sequence of methylation detection probes within the CpG island (located at chr7:152435133–152437025, assembly GRCh38/hg38) that encompasses the KMT2C promoter region.
  2. Comparison of the methylation levels of the above probes in tumor samples and normal bladder tissue. Methylation data were obtained from TCGA through the MethHC database for n = 21 healthy/tumor pairs. Wilcoxon matched‐pairs signed‐rank test was used.
  3. Tumor vs. normal paired comparison of the methylation levels in the KMT2C promoter in various cancer types; cg1: cg17322443; cg2: cg19258062. Methylation data were obtained from the MethHC database (Huang et al 29). BC: n = 21, COAD: n = 21, NSCLC: n = 70, HNSCC: n = 50. For NSCLC analysis, separate cohorts from adenocarcinoma and squamous cell carcinoma were combined. Separate analysis of the two NSCLC subtypes yielded the same results. Wilcoxon matched‐pairs signed‐rank test was used. * designates P‐value < 0.05 and ****P‐value < 0.0001.