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. Author manuscript; available in PMC: 2019 Jul 9.
Published in final edited form as: Nature. 2019 Jan 9;565(7739):382–385. doi: 10.1038/s41586-018-0840-5

Figure 1 |. Structures of Mtb transcription initiation complexes with AP3 promoter DNA.

Figure 1 |

A. Mtb AP3 promoter9 fragment used for cryo-EM. The core promoter elements and the TSS (+1) are denoted.

B. Overall structure of Cor-RP2. Proteins are shown as transparent surfaces and color-coded as shown in the key. The Cor and DNA (labeled with the −35, −10 elements and +1 colored as in (A)) are shown with transparent cryo-EM difference density and colored as labeled.

C. Overall structures of RPo and RP2. Proteins and DNAs are shown as in (B) with DNA colors as labeled.

D. Superposed DNAs (colored as in B and C) from RPo, Cor-RP2, and RP2.