. Author manuscript; available in PMC: 2019 Jul 9.

Published in final edited form as: Nature. 2019 Jan 9;565(7739):382–385. doi: 10.1038/s41586-018-0840-5

Extended Data Table 2 |.

Structural superpositions.

Structural core module^a
subunit	Mtb RNAP residues	Thermus aquaticus residues
αI, αII, ω	complete	complete
β	1–53; 177–182; 370–380; 445–639; 705–747; 879–1116	1–18; 138–143; 325–335; 400–592; 658–700; 833–1080
β’	414–443; 496–863; 1246–1282	615–644; 700–1084; 1460–1488
alignments^b
		Rmsd (Å)	# of Cα’s
Taq RPo (4XLN-A) ➔ Mtb RPo		1.226	1147
Taq RPo (4XLN-B) ➔ Mtb RPo		1.226	1147
Taq CarD-RPo (4XLR-B) ➔ Mtb RPo		1.338	1150
Mtb Cor-RP2 ➔ Mtb RPo		0.475	1390
Mtb Cor-RbpA/σ^A-holo ➔ Mtb RPo		0.619	1399
Mtb RP2 ➔ Mtb RPo		0.342	1326
Mtb RbpA/σ^A-holo (6C05) ➔ Mtb RPo		0.825	1397
Mtb Fdx-RbpA/σ^A-holo (6BZO) ➔ Mtb RPo		0.566	1363

The structural core module comprises the α subunits, the ω subunit, and conserved β and β’ regions around the RNAP active center that have not been observed to undergo significant conformational changes.

Alignments performs using the PyMOL ‘align’ command.