Table 1.
Mixed-ANOVA of P300 variables for SCA2 patients, preclinical carriers and healthy controls
ERP | Variable | SCA2 patients | Preclinical carriers | Healthy controls | Mixed-ANOVA | ||
---|---|---|---|---|---|---|---|
Group | Site | Group x Site | |||||
Visual | Latency | ||||||
Cz | 462.80 ± 7.40***/¶¶ | 421.34 ± 9.06* | 384.68 ± 7.08 | F = 53.73 | F = 0.12 | F = 0.10 | |
Pz | 463.41 ± 7.40***/¶¶ | 420.46 ± 9.92ns | 390.54 ± 8.10 | p < 0.0001 | p > 0.05 | p > 0.05 | |
Amplitude | |||||||
Cz | 9.23 ± 1.12** | 11.63 ± 1.41ns | 15.28 ± 1.10 | F = 14.00 | F = 0.20 | F = 0.06 | |
Pz | 9.03 ± 1.15** | 11.44 ± 1.43ns | 14.39 ± 1.09 | p < 0.0001 | p > 0.05 | p > 0.05 | |
Auditory | Latency | ||||||
Cz | 437.91 ± 8.88***/¶¶ | 380.66 ± 10.88ns | 358.05 ± 9.64 | F = 41.18 | F = 1.09 | F = 0.61 | |
Pz | 438.21 ± 9.79*** | 401.67 ± 11.79* | 360.94 ± 10.76 | p < 0.0001 | p > 0.05 | p > 0.05 | |
Amplitude | |||||||
Cz | 9.47 ± 1.25* | 12.63 ± 1.51ns | 16.99 ± 1.29 | F = 9.47 | F = 0.263 | F = 0.03 | |
Pz | 9.48 ± 1.11* | 11.48 ± 1.33ns | 15.50 ± 1.22 | p < 0.0001 | p > 0.05 | p > 0.05 |
Asterisks denote the statistical differences between SCA2 patients or preclinical carriers and controls (*:p < 0.05; **:p < 0.005; ***:p < 0.0005). Pilcrow denote the statistical differences between SCA2 patients and preclinical carriers (¶¶: p < 0.005)