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. 2019 Mar 5;16:10. doi: 10.1186/s12014-019-9230-8

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Diagnostic performance of serum biomarkers individually and combination for the detection of UM. a and c Receiver operator characteristics (ROC) curves for OPN, MIA, CEACAM-1, MIC-1, SPON1, POSTN, and HSP27 as individual markers and HSP27 and OPN combined for UM patients versus healthy controls. b and d ROC curves for OPN, MIA, CEACAM-1, MIC-1, SPON1, POSTN, and HSP27 as individual markers and MIA and MIC-1 combined for metastatic UM versus DF (≥ 5 years). The area under the curve (AUC) for each marker or panel is presented along with its 95% confidence interval in brackets