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. 2019 Mar 4;38:112. doi: 10.1186/s13046-019-1043-0

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — High expression levels of FAT4 could inhibit the EMT and induce autophagy in CRC. a-c Immunofluorescence staining was performed to detect the expression of FAT4 in cells transduced with FAT4 shRNA or a FAT4-overexpression vector compared with that in cells transfected with the negative control. The results revealed that LC3 expression was elevated in the FAT4-overexpressing LOVO and HCT116 cells, whereas FAT4 knockdown inhibited the expression of LC3 in SW480 cells. a-c In addition, in HCT116 and LOVO cells, FAT4 overexpression increased E-cadherin expression, thereby inhibiting the EMT, whereas in SW480 cells, FAT4 knockdown suppressed E-cadherin expression