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. 2019 Feb 25;25:1499–1505. doi: 10.12659/MSM.914899

Figure 3.

Figure 3

Serum hsa_circ_0000885 levels were increased in serum from patients with osteosarcoma. (A) Expression levels of hsa_circ_0000885 in 30 patients with osteosarcoma, 27 patients with benign bone tumors, and 25 age-matched and sex-matched healthy controls were analyzed by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and normalized to the GAPDH level. (B) Relative expression of hsa_circ_0000885 in 11 patients with osteosarcoma, Enneking stage I or IIA and 19 patients with osteosarcoma, Enneking stage IB or III. (C) Relative expression of hsa_circ_0000885 in 20 patients with osteosarcoma without metastasis and 10 patients with osteosarcoma with lung metastasis. (D) Relative expression of hsa_circ_0000885 in 30 patients with osteosarcoma before and after chemotherapy. (E) Relative expression of hsa_circ_0000885 in 30 patients with osteosarcoma before and after surgery. (F) Receiver operating characteristic (ROC) curve shows the diagnostic value of hsa_circ_0000885 in distinguishing between patients with osteosarcoma from healthy individuals. (G) ROC curve shows the diagnostic value of hsa_circ_0000885 in distinguishing between patients with osteosarcoma and benign bone tumors.