Table 2.
Factors influencing the disease-free survival (DFS) and overall survival (OS) in patients with osteosarcoma.
| Variables | Disease-free survival | Overall survival | ||
|---|---|---|---|---|
| HR | P-value | HR | P-value | |
| Univariate analysis | ||||
| Gender (Male/Female) | 0.873 | 0.679 | 0.954 | 0.895 |
| Age (<25, ≥25 years) | 0.897 | 0.739 | 0.752 | 0.437 |
| Enneking stage (I, IIA or IIB, III) | 3.504 | 0.002 | 4.001 | 0.002 |
| Lung metastasis (yes/no) | 6.090 | <0.001 | 5.757 | <0.001 |
| Tumor size (≤5, >5 cm) | 1.328 | 0.396 | 1.030 | 0.936 |
| hsa_circ_0000885 expression (low, high) | 3.356 | <0.001 | 4.247 | <0.001 |
| ALP (normal, abnormal) | 1.111 | 0.747 | 1.249 | 0.533 |
| Multivariate analysis | ||||
| Enneking stage (I, IIA or IIB, III) | 2.164 | 0.091 | 2.226 | 0.121 |
| Lung metastasis (yes, no) | 3.382 | 0.005 | 2.996 | 0.021 |
| hsa_circ_0000885 expression (high, low) | 1.924 | 0.099 | 2.458 | 0.047 |
OS – osteosarcoma; ALP – alkaline phosphatase; hsa_circ_0000885 expression high/low – the expression of hsa_circ_0000885 in osteosarcoma tissue was higher/lower than the median.