Table 1.
Eight candidate genes that exhibit modulation of r(CGG)90 toxicity in Drosophila
| No. | Mouse gene | Drosophila ortholog | BDSC stock | Effect on r(CGG)90 toxicity | |
|---|---|---|---|---|---|
| 1 | Cda | Cytidine deaminase | CG8353 | 51915 | Enhanced |
| 2 | Cers5 | Ceramide synthase 5 | Schlank | 29340 | Enhanced |
| 3 | Chat | Choline O-acetyltransferase | ChAT | 60028 | Enhanced |
| 4 | Coasy | Coenzyme A synthase | Ppat-Dpck | 57231 | Enhanced |
| 5 | Ggct | Gamma-glutamylcyclotransferase | CG4306 | 65890 | Suppressed |
| 6 | Impdh1 | Inosine monophosphate dehydrogenase 1 | Ras | 31653 | Enhanced |
| 7 | Pcyt2 | Phosphate cytidylyltransferase 2, ethanolamine | Pect | 63710 | Enhanced |
| 8 | Sphk1 | Sphingosine kinase 1 | Sk2 | 36741 | Enhanced |