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. 2018 Nov 27;28(6):992–1006. doi: 10.1093/hmg/ddy411

Figure 5.

Figure 5

Nrg1TIII overexpression increases cholesterol and fatty acids levels. Lipidomic analysis was performed on P28 sciatic nerves. (A) The level of free cholesterol increased in HANI as compared with WT, whereas no differences were detected between S63del and HANI/+//S63del nerves. (B) Levels of total saturated (palmitic acid, C16:0; stearic acid, C18:0; behenic acid, C22:0 and lignoceric acid, C24:0) and total unsaturated (oleic acid, C18:1; linoleic acid, C18:2; erucic acid, C22:1 and nervonic acid, C24:1) fatty acids and (C) the relative desaturation index (ratio 18:0/18:1) and membrane fluidity index (ratio 18:1/18:2). Data are expressed as μg of cholesterol or ng of fatty acid normalized to μg of total proteins. *P < 0.05, **P < 0.01, ***P < 0.001 versus WT by one-way ANOVA with Bonferroni’s multiple comparison test. Five sciatic nerves from different animals per genotype were analyzed.