Table 2.

Median CD4 cell count, viral load, and RPR^a titer at the time of syphilis diagnosis^b by syphilis stage and ocular syphilis (OS) status in syphilis patients with a previous^c and concurrent^d HIV diagnosis reported in North Carolina, 2014-2016.

			Previous HIV Diagnosis^c			Concurrent HIV Diagnosis^d			Total HIV-Positive Syphilis Cases
			Median	IQR^e	p^f	Median	IQR^e	p^f	Median	IQR^e	p^f
CD4 Count (cells/ml)	Primary/Secondary	Non-OS^g	496	329-719		422	248-575		480	309-694
	Primary/Secondary	OS^g	308	125-765	0.2	398	152-629	0.9	360	129-708	0.2
	Non-Primary/Non-Secondary Early	Non-OS	570	372-773		434	215-572		551	362-761
	Non-Primary/Non-Secondary Early	OS	510	108-586	0.2	280	280-280	0.5	479	108-586	0.1
	Late or Unknown Duration	Non-OS	526	350-720		327	140-498		490	310-680
	Late or Unknown Duration	OS	515	369-657	0.7	260	221-325	0.3	388	260-566	0.2
	TOTAL	Non-OS	529	350-740		379	218-550		507	327-718
	TOTAL	OS	485	218-703	0.1	280	221-398	0.1	388	221-629	0.009
Viral Load (copies/ml)	Primary/Secondary	Non-OS	30	20-9400		60,111	19,195-134,000		60	20-31,400
	Primary/Secondary	OS	502	20-84283	0.09	62,890	24,670-143,000	0.9	1550	20-86,825	0.2
	Non-Primary/Non-Secondary Early	Non-OS	20	20-140		41,620	12,560-117,130		20	20-1,924
	Non-Primary/Non-Secondary Early	OS	20	20-40	0.8	48,494	48,494-48,494	0.8	20	20-48,494	0.9
	Late or Unknown Duration	Non-OS	21	20-2870		59,117	13,510-165,561		59	20-26,595
	Late or Unknown Duration	OS	20	20-248	0.6	64,613	52,100-81,195	0.5	444	20-64,613	0.3
	TOTAL	Non-OS	20	20-1670		54,995	16,972-147,000		40	20-18,470
	TOTAL	OS	37	20-9106	0.3	63,710	48,494-81,195	0.4	482	20-25,780	0.03
RPR titer	Primary/Secondary	Non-OS	64	32-256		64	32-128		64	16-128
	Primary/Secondary	OS	128	32-512	0.2	64	64-128	0.9	64	32-128	0.2
	Non-Primary/Non-Secondary Early	Non-OS	32	8-128		32	16-128		32	8-64
	Non-Primary/Non-Secondary Early	OS	192	128-512	0.04	512	512-512	0.1	256	64-256	0.01
	Late or Unknown Duration	Non-OS	32	8-128		32	4-128		16	2-32
	Late or Unknown Duration	OS	256	64-512	0.0001	128	64-256	0.009	128	64-256	<0.0001
	TOTAL	Non-OS	64	16-128		64	16-128		32	8-64
	TOTAL	OS	128	64-512	<0.0001	128	64-256	0.02	64	64-256	<0.0001

^a.

RPR=Rapid plasma regain titer, a serologic test to screen for syphilis. The titer refers to the greatest dilution of serum at which the test is still positive.[18]

^b.

CD4 cell count and viral load reported closest to and within six months of the syphilis diagnosis date in the NC Engagement in Care and HIV Outreach database

^c.

HIV diagnosis date >30 days prior to syphilis diagnosis date

^d.

HIV diagnosis date ≤30 days from the syphilis diagnosis date

^e.

IQR=Interquartile Range

^f.

p-value based on Wilcoxon Rank Sum Test comparing Median OS value versus Non-OS value

^g.

OS=Ocular Syphilis Patient; Non-OS=not an ocular syphilis patient