Table 3.
Minimal inhibitory concentration of extract and isolated compounds from P. uviferum, and antibiotics and mixtures against S. aureus strains.
| Minimal inhibitory concentration (μg/mL) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Antibiotic plus sample | ||||||||||
| S. aureus strains | Antibiotic alone a | Sample alone b | CIP + DCME | CIP + C4 | CIP + C6 | OX + DCME | OX + C4 | OX + C6 | ||
| WT | CIP | 1.0 | DCME | 62.5 | 0.125 (8) | 0.015 (67) | 0.015 (67) | 1.5 (8) | 1.5 (8) | 1.5 (8) |
| OX | 12.5 | EP | 31.3 | |||||||
| 15-C | 31.3 | |||||||||
| K2378 | CIP | 2.0 | DCME | 125 | 0.25 (8) | 0.125 (16) | 0.25 (8) | 3.12 (8) | 3.12 (8) | 3.12 (8) |
| OX | 25 | EP | 125 | |||||||
| 15-C | 31.3 | |||||||||
| K1902 | CIP | 0.5 | DCME | 62.5 | 0.065 (8) | 0.065 (8) | 0.031 (16) | 1.56 (8) | 3.12 (4) | 1.56 (8) |
| OX | 12.5 | EP | 62.5 | |||||||
| 15-C | 62.5 | |||||||||
WT, wild type (NCTC 8325-4); K1902, norA-deleted; K2378, overexpressing norA. a CIP, ciprofloxacin; NOR, norfloxacin; OX, oxacillin. b DCME, dichloromethane extract; C4, epi-cubenol; C6, 15-copaenol. ( ), Fold of reducing the MIC of the antibiotic in combination with extract or pure compounds. MIC values are referred to FIC values in Table 4.