Fig.3.

NP103 shows minor effects on lifespan extension of pathogenic tau aex-3/T337 transgenic strain but improves their paralysis phenotype. A) Dose–response Kaplan–Meier survival curve of synchronized mutant aex-3/T337 worms exposed to different doses (0–250 μM) of NP103. B) Curve representing the percentage of aex-3/T337 worms non-treated (black line) or NP103 100 μM treated (purple line) showing wild type-like movement along time. One representative experiment out of three independent assays are shown in (A) and (B); (n = 20 worms per experiment and dose). C) Statistical analysis of aex-3/T337 worms motility after 5 days of treatment with vehicle (control, C) or 100 μM NP103 (NP). Motility was scored assigning different values to worms with normal wild type-like movement (value 3), slow movement (value 2) or paralyzed (value 1). Data show means±s.e.m of three independent experiments (n = 20 worms per experiment). Chi-square test was performed (^*p < 0.05).