Table 3.
Univariate and multivariate Cox regression analyses of prognostic parameters for overall survival in propensity score matching cohorts
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| P-value | HR | 95% CI | P-value | HR | 95% CI | |
| Gender | 0.132 | 1.816 | 0.835–3.949 | – | – | – |
| Age | 0.249 | 0.983 | 0.956–1.012 | – | – | – |
| ECOG PS | 0.033 | 1.935 | 1.055–3.552 | 0.009 | 2.480 | 1.259–4.886 |
| Tumor location | 0.319 | 0.711 | 0.364–1.390 | – | – | – |
| Differential degree | 0.638 | 0.915 | 0.632–1.325 | – | – | – |
| AJCC stage | 0.116 | 1.738 | 0.872–3.463 | – | – | – |
| Initial CEA | 0.187 | 1.002 | 0.999–1.006 | – | – | – |
| Initial CA199 | 0.009 | 1.001 | 1.000–1.002 | 0.021 | 1.001 | 1.000–1.002 |
| Surgery history | 0.372 | 0.756 | 0.410–1.396 | – | – | – |
| Radiotherapy history | 0.647 | 1.209 | 0.536–2.728 | – | – | – |
| Apatinib dosage | 0.461 | 1.269 | 0.674–2.390 | – | – | – |
| Treatment lines | 0.336 | 0.720 | 0.368–1.407 | – | – | – |
| Treatment options | 0.022 | 0.504 | 0.280–0.907 | 0.003 | 0.377 | 0.198–0.720 |
Abbreviations: AJCC, American Joint Committee on Cancer; CA199, carbohydrate antigen 199; CEA, carcinoembryonic antigen; ECOG PS, Eastern Cooperative Oncology Group performance status; GEJ, gastroesophageal junction.