Table 1.

Summary of Treatment Regimens^a

Agent	Dose	Route	Schedule
Trebananib Monotherapy (Arm A)
Trebananib	15 mg/kg	IV	Day 1, 8, 15, 22, 29, and 36
Trebananib + continued anti-VEGF therapy (Arm B)
Trebananib	15 mg/kg	IV	Day 1, 8, 15, 22, 29, and 36
plus ONE of the following anti-VEGF agents:
Bevacizumab	10 mg/kg	IV	Day 1, 15, and 29
Pazopanib	800 mg once dailyb	Oral	Days 1–42
Sorafenib	400 mg twice dailyb	Oral	Days 1–42
Sunitinib	50 mg once dailyb	Oral	Days 1–28

^aCycle length is 42 days on both Arms.

^bThe standard starting dose is given. Patients may have started at a lower dose based on toxicity during prior administration.