Table 1.
Over-represented KEGG pathways following automated KEGG analysis of differentially expressed genes (DEGs) in macrophages stimulated with curdlan or MacroGard®.
| Pathway | Curdlan | MacroGard® |
|---|---|---|
| Phagosome | X | |
| Cytokine-cytokine receptor interaction | X | X |
| Lysosome | X | |
| Apoptosis | X | X |
| Herpes simplex infection | X | |
| Toll-like receptor signalling pathway | X | |
| NOD-like receptor signalling pathway | X | X |
| VEGF signalling pathway | X | |
| Arachidonic acid metabolism | X | |
| Metabolic pathways | X | |
| Phosphatidylinositol signalling system | X | |
| ECM-receptor interaction | X | X |
| Adipocytokine signalling pathway | X |
Curdlan-DEGs (n = 356 genes) could be mapped to n = 92 pathways, of which n = 4 were significantly over-represented. MacroGard®-DEGS (n = 541 genes) could be mapped to n = 112 pathways of which n = 13 were significantly over-represented. KEGG analysis was performed with KOBAS v3.0 with Chi-square test and the Benjamini and Yekutieli method for FDR correction. Pathways were considered significantly over-represented at corrected p-value ≤ 0.05.