Table 3.
Comparison of clinical features at baseline and 6 months between patients with negative cultures for vaginal Candida at baseline who converted to positive cultures and who remained negative at 6 months after taking sodium–glucose cotransporter 2 inhibitors
| Converted to positive (n = 24) | Remained negative (n = 41) | P‐value | |
|---|---|---|---|
| Age (years) | 57.9 ± 9.2 | 49.9 ± 10.5 | <0.01 |
| Known duration of diabetes (years) | 11.1 ± 7.4 | 8.0 ± 6.8 | NS |
| Body mass index (kg/m2) | 32.3 ± 5.0 | 31.1 ± 5.2 | NS |
| HbA1c, % (mmol/mol) | 7.1 ± 0.8 (58 ± 5) | 7.6 ± 1.2 (57 ± 7) | NS |
| Systolic blood pressure (mmHg) | 120 ± 14 | 123 ± 14 | NS |
| Albuminuria (mg/gCr†) | 16.3 (11.3–31.5) | 8.3 (4.9–21.5) | <0.05 |
| eGFR (mL/min/1.73 m2) | 81.5 ± 22.3 | 84.3 ± 22.0 | NS |
| Retinopathy (%) | 25.0 | 14.6 | NS |
| Neuropathy (%) | 50.0 | 24.4 | <0.05 |
| Any microangiopathy | 62.5 | 36.6 | <0.05 |
| Postmenopause (%) | 87.5 | 53.7 | <0.01 |
| Positive for urinary WBC (%) | 26.1 | 16.2 | NS |
| At 6 months | |||
| Body mass index (kg/m2) | 30.9 ± 5.1 | 29.8 ± 5.1 | NS |
| ΔBMI | −1.4 ± 0.9 | −1.3 ± 1.1 | NS |
| HbA1c (%) | 7.1 ± 0.6 | 7.0 ± 0.8 | NS |
| ΔA1C | −0.01 ± 0.7 | −0.55 ± 1.0 | <0.05 |
†Median and interquartile range are given. BMI, body mass index; eGFR; estimated glomerular filtration rate, HbA1c, glycated hemoglobin; NS, not significant; WBC; white blood cell.