Table 3. Potential fetuin-B orthologs in vertebrates.
All sequences contain the intact CPDCP-trunk motif. UP, UniProt; GB, GenBank. Sequence identity with human fetuin-B was determined only for mammalian sequences, as they share the same overall protein length and architecture. Other vertebrate sequences share domains CY1 and CY2 but have highly variable CTRs.
| Organism | Database code | Sequence identity† (%) | Hairpin I sequence |
|---|---|---|---|
| Mammals | |||
| Human (Homo sapiens) | UP Q9UGM5 | 100 | QWVVGP |
| Western lowland gorilla (Gorilla gorilla) | UP G3QMB1 | 98 | QWVVGP |
| Chimpanzee (Pan troglodytes) | UP A0A2J8M5X2 | 97 | QWVVGP |
| Sumatran orangutan (Pongo abelii) | UP A0A2J8WHT1 | 97 | QWVVGP |
| Fruit bat (Pteropus vampyrus) | GB XP_011380247 | 75 | QWVFGP |
| African elephant (Loxodonta africana) | UP G3SVW6 | 70 | QWVVGP |
| Dog (Canis lupus familiaris) | UP E2R9B6 | 69 | QWVYGP |
| Sperm whale (Physeter catodon) | GB XP_007116341 | 69 | QWVFGP |
| Naked mole rat (Heterocephalus glaber) | UP G5BT88 | 67 | QWVVGP |
| European hedgehog (Erinaceus europaeus) | GB XP_007519827 | 66 | QWVFGP |
| Bovine (Bos taurus) | UP Q58D62 | 66 | QWVFGP |
| Horse (Equus caballus) | UP F6RRV1 | 63 | QWVVGP |
| Mouse (Mus musculus) | UP Q9QXC1 | 63 | QWVSGP |
| Rat (Rattus norvegicus) | UP Q9QX79 | 61 | QWVVGP |
| Pig (Sus scrofa) | UP F1SFI6 | 60 | QWVFGP |
| Koala (Phascolarctus cinereus) | GB XP_020844617 | 50 | QWVFGP |
| Opossum (Monodelphis domestica) | GB XP_001373317 | 47 | QWVVGP |
| Birds | |||
| Mallard (Anas platyrhynchos) | UP U3IFE7 | QMVIGP | |
| Zebra finch (Taeniopygia guttata) | UP H0ZJK5 | QWVIGP | |
| Rock dove (Columba livia) | UP F1NHT5 | QWVIGP | |
| Collared flycatcher (Ficedula albicollis) | UP U3K0K6 | QWVVGP | |
| Reptiles | |||
| American chameleon (Anolis carolinensis) | UP H9GD35 | QWVVGP | |
| Bearded dragon (Pogona vitticeps) | GB XP_020666227 | QWVVGP | |
| Chinese softshell turtle (Pelodiscus sinensis) | UP K7GGY5 | QWVIGP | |
| Chinese alligator (Alligator sinensis) | UP A0A1U7RBY2 | QWVVGP | |
| Burmese python (Python bivittatus) | GB XP_025031668 | QWVVGP | |
| Amphibians | |||
| African clawed frog (Xenopus laevis) | UP Q7SYH2 | QWVVGP | |
| Western clawed frog (Xenopus tropicalis) | GB XP_002937874 | QWVVGP | |
| High Himalaya frog (Nanorana parkerii) | GB XP_018422589 | QWMFGQ | |
| Axolotl (Ambystoma mexicanum) | ‡ | QWVFGP | |
| Bony fishes | |||
| Channel catfish (Silurus punctatus) | UP W5UDH5 | QWIVGP | |
| Rainbow trout (Oncorhynchus mykiss) | GB XP_021460414 | QWVVGP | |
| Atlantic salmon (Salmo salar) | UP A0A1S3KKB8 | QWVVGP | |
| Turbot (Scophthalmus maximus) | UP A0A221J5J5 | QWVVGP | |
| Three-spined stickleback (Gasterosteus aculeatus) | UP G3NQ86 | QWVVGP | |
| Nile tilapia (Oreochromis niloticus) | UP I3JY83 | QWVVGP | |
| Japanese killifish (Oryzias latipes) | UP H2MAI0 | QWVVWP | |
| Zebrafish (Danio rerio) | UP A5D6T5 | QWMVGA | |
| Coelacanth (Latimeria chalumnae) | UP M3XK68 | QWMVGA | |
| Cartilaginous fishes | |||
| Elephant shark (Callorhincus milii) | GB XP_007897454 | QGMFFE | |
†
With human fetuin-B.
‡
http://www.ambystoma.org/index.php?option=com_content&view=article&id=67:ambystoma-get-contig&catid=40:codepages&Itemid=2&species=2&mcid=contig331328.