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. Author manuscript; available in PMC: 2019 Mar 5.
Published in final edited form as: Angew Chem Int Ed Engl. 2017 Sep 26;56(44):13732–13735. doi: 10.1002/anie.201707707

Figure 3.

Figure 3

Rationale for the inhibition of the PD-1/PD-L1 interaction by the macrocyclic peptides. Macrocyclic peptides bind to PD-L1 at the site of PD-1, however, the detailed interactions are different. A) The peptides -57 (blue) and -71 (yellow) bind to PD-L1 partially at the site of the PD-1 interaction (magenta). B)-C) Detailed interactions of peptide-71 at the binding surface of PD-L1 in comparison with the PD-1/PD-L1 interactions. D)-E) Detailed interactions of peptide-57 at the binding surface of PD-L1 in comparison with the PD-1/PD-L1 interactions.