Table 2.
Meta-analysis results for B cell NHL overall and by HIV serostatus
| All subgroups |
HIV serostatus subgroups |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Q Test† |
HIV+ | HIV- | Meta-regression ROR‡ (95% CI) for HIV+ / HIV- | P‡ | |||||||
| Biomarker | No. | OR (95% CI) | I2* (95% CI) | Q-statistic | P | OR (95% CI) | I2 (95% CI) | OR (95% CI) | I2 (95% CI) | ||
| IL-6 | 10 | 1.22 (0.97 to 1.54) | 80 (65 to 89) | 45.61 | <.001 | 2.07 (1.19 to 3.60) | 82 (44 to 94) | 1.01 (0.97 to 1.06) | 0 (0 to 69) | 1.96 (1.53 to 2.50) | <.001 |
| IL-10 | 8 | 1.24 (0.93 to 1.63) | 82 (65 to 90) | 38.43 | <.001 | 1.20 (0.64 to 2.24) | —§ | 1.25 (0.91 to 1.72) | 84 (69 to 92) | 0.96 (0.33 to 2.83) | .943 |
| TNF-α | 9 | 1.18 (1.04 to 1.34) | 63 (23 to 82) | 21.46 | .035 | 1.79 (1.35 to 2.37) | 0 (– to –) | 1.12 (1.02 to 1.23) | 44 (0 to 76) | 1.58 (1.15 to 2.18) | .005 |
| CXCL13 | 5 | 1.47 (1.03 to 2.08) | 89 (78 to 95) | 37.00 | <.001 | 2.56 (1.32 to 4.96) | — | 1.35 (0.95 to 1.92) | 91 (79 to 96) | 1.89 (0.69 to 5.23) | .218 |
| sCD23 | 4 | 1.57 (1.21 to 2.05) | 90 (77 to 96) | 29.24 | <.001 | 1.59 (1.23 to 2.06) | 0 (– to –) | 1.58 (0.93 to 2.66) | 0 (0 to 69) | 1.00 (0.54 to 1.87) | .996 |
| sCD27 | 7 | 2.18 (1.20 to 3.98) | 92 (87 to 96) | 79.67 | <.001 | 4.93 (3.00 to 8.08) | 0 (– to –) | 1.61 (0.89 to 2.93) | 84 (69 to 92) | 3.35 (1.05 to 10.71) | .041 |
| sCD30 | 9 | 1.65 (1.22 to 2.22) | 90 (84 to 94) | 83.01 | <.001 | 3.69 (2.40 to 5.69) | 11 (– to –) | 1.40 (1.11 to 1.76) | 44 (0 to 76) | 2.55 (1.38 to 4.73) | .003 |
*
Higgins’ I2 statistic measuring the proportion of the observed variance between studies relative to the total variance of a set of studies. CI = confidence interval; OR = odds ratio; ROR= ratio of odds ratios.
†
Q test assessing the degree to which study effect sizes are concordant.
‡
The ratio of odd-ratios compares the odds-ratio for the HIV+ subgroup with that of the HIV- subgroup (HIV+/HIV-). The corresponding P values are computed from a test of the null hypothesis of no difference between the serostatus groups.
§
“—” and “–” denote Higgins’ I2 statistics and confidence intervals that were not calculated because of inadequate sample size, n = 1 and n = 2, respectively.