Table 2:

Multivariate analysis of prognostic variables for Overall Survival (OS) and Disease Specific Survival (DSS) in patients with kidney cancer who received care with Northern California Kaiser Permanente General from 1998–2008

	Overall Survival			Disease-specific Survival
Variable	Hazard Ratio	95% CI	p value	Hazard Ratio	95% CI	p value
Age	1.04	1.03–1.05	<0.0001	1.01	1.00–1.02	0.165
Gender			0.027			1.265
Male	1.00 (ref)			1.00 (ref)
Female	0.83	0.71–0.98		0.99	0.79–1.27
Race			0.113			0.031
White	1.00 (ref)			1.00 (ref)
Hispanic	1.18	0.96–1.45		1.38	1.03–1.84
Any Renal Disease	0.67	0.44–1.02	0.063	1.38	0.50–3.77	0.533
Diabetes	0.68	0.56–0.82	<0.0001	1.03	0.76–1.40	0.853
Tumor size (cm)	1.04	1.027–1.047	<0.0001	1.05	1.04–1.06	<0.0001
Tumor Grade			<0.0001			<0.0001
Grade 1	0.45	0.33–0.62	<0.0001	0.25	0.16–0.40	<0.0001
Grade 2	0.4	0.31–0.51	<0.0001	0.26	0.19–0.36	<0.0001
Grade 3	0.53	0.41–0.68	<0.0001	0.55	0.41–0.73	<0.0001
Grade 4	1.00 (ref)			1.00 (ref)
Histological Subtype						0.364
Clear Cell	1.00 (ref)			1.00 (ref)
Papillary	0.92	0.62–1.38	0.695	0.9	0.42–1.92	0.78
Others	0.89	0.70–1.12	0.326	0.81	0.58–1.12	0.199
AJCC Stage			<0.0001			<0.0001
Stage 1 & 2	1.00 (ref)			1.00 (ref)
Stage 3 & 4	2.69	2.30–3.14		7.65	5.88–9.96
Treatment Status			<0.0001			<0.0001
Surgery	1.00 (ref)			1.00 (ref)
No Surgery	3.79	2.95–4.88		5.74	4.23–7.81	<0.0001