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. Author manuscript; available in PMC: 2020 Feb 20.
Published in final edited form as: J Am Chem Soc. 2019 Feb 6;141(7):2960–2974. doi: 10.1021/jacs.8b10558

Figure 1.

Figure 1.

Targaprimir-515/885 (1) and Targaprimir-515 (2) target the Drosha sites in pri-miR-515. (A) Pathway of miR-515 affecting sphingosine kinase 1 (SK1), sphingosine 1-phosphate (S1P), triggering cell proliferation. (B) Secondary structures of the miR-885 and miR-515 hairpin precursors, with Drosha processing sites and 1-binding sites indicated with blue boxes. (C) Structures of 1 and 2, which have four propylamine spacers between 1 RNA-binding modules.