Table 3.

Changes by Cohort

Change Type	Change to Intervention	Reason for Change
COHORT 1
Contingency Management	Added a $100 bonus for abstinence at 3 months after quitting	Patient data and empirical evidence from other studies
	Switched participants to use the iCO Smokerlyzer (plugs into the smartphone)	Participant and therapist feedback
	Exhale for CO readings must be audible and last at least a few seconds	Therapist feedback
	Messages within the mCM app provided feedback and encouragement to participants	Therapist feedback
Pharmacotherapy	Heavy smokers (30+ cigarettes per day) receive a 42mg nicotine patch	Patient data and empirical evidence from other studies
	Participants start using NRT on the quit date regardless of quit status	Patient data and empirical evidence from other studies
	Participants instructed to use 10 lozenges/ pieces of nicotine gum per day after quitting	Participant data and therapist feedback
	Participants answered daily prompts within the app measuring their use of pharmacotherapy	Therapist feedback
Psychotherapy	Review personalized reasons for quitting at every therapy session	Therapist feedback
Relapse Prevention	Removed Stay Quit Coach smartphone app	Participant and therapist feedback
COHORT 2
Contingency Management	Enhanced and extended practice video period	Therapist feedback
	Increased reinforcement for smoking abstinence in the first 3 days of quitting	Therapist feedback and patient data
	If unable to achieve initial abstinence, participants encouraged to reset the quit day and restart CM	Therapist feedback
Pharmacotherapy	Added varenicline for participants unable to stop within the first week of the quit date	Patient data and empirical evidence from other studies [cite]
Psychotherapy	Sessions 1 and 3 held in-person sessions if preferred by participant	Therapist feedback
	New user-friendly therapist manual and accompanying patient workbook	Consultant feedback
	Patients encouraged to repeat session 3 if they were unable to quit	Participant data and consultant feedback