Table 1.
Summary of demographic and clinical characteristics of HIV-infected participants, before and after TDF initiation
| Pre-TDF (n=198) |
On TDF (~ year 1)* (n=198) |
P-value | |
|---|---|---|---|
| Age, years | 48 (41, 54) | 49 (42, 56) | — |
| Female | 111 (56%) | — | |
| Race | |||
| African American | 126 (64%) | ||
| White | 59 (30%) | — | |
| Other | 13 (7%) | ||
| Smoking | |||
| Current | 73 (37%) | 70 (35%) | 0.83 |
| Past | 62 (31%) | 66 (33%) | |
| Never | 62 (31%) | 62 (31%) | |
| Diabetes mellitus | 32 (17%) | 32 (17%) | 1.00 |
| Systolic BP, mmHg | 126 (114, 137) | 122 (113, 135) | 0.18 |
| Diastolic BP, mmHg | 77 (71, 86) | 77 (71, 85) | 0.47 |
| Antihypertensive use | 70 (35%) | 77 (39%) | 0.14 |
| History of CVD | 13 (7%) | 16 (8%) | 0.08 |
| Hepatitis C virus-infected | 33 (17%) | 34 (17%) | 0.32 |
| Serum creatinine, mg/dL | 0.85 (0.72, 0.95) | 0.91 (0.79, 1.0) | <0.001 |
| eGFR, ml/min/1.73m2 | 103 (88, 116) | 95 (79, 111) | <0.001 |
| LDL, mg/dL | 101 (79, 121) | 97 (71, 121) | 0.29 |
| HDL, mg/dL | 46 (38, 57) | 47 (38, 57) | 0.35 |
| TG, mg/dL | 113 (79, 172) | 114 (80, 167) | 0.95 |
| Serum albumin, g/dL | 4.2 (3.8, 4.4) | 4.3 (4.0, 4.5) | 0.01 |
| Current CD4, cells/mm3 | 483 (338, 682) | 587 (416, 743) | 0.003 |
| Nadir CD4, cells/mm3 | 347 (223, 471) | 340 (215, 458) | 0.68 |
| HIV RNA < 80 copies/mL | 56 (29%) | 162 (82%) | <0.001 |
| ART use | 79 (40%) | 198 (100%) | <0.001 |
| BMI, kg/m2 | 27 (23, 32) | 28 (24, 33) | 0.51 |
| Waist Circ., cm | 94 (83, 104) | 97 (85, 107) | 0.19 |
Data are presented as Median (IQR) or numbers (percent). P-values testing within-subject changes from baseline from Wilcoxon signed-rank test or McNemar’s test.
*
On TDF represents study visit corresponding to biomarker measurement closest to time at which participant had reached 1 year of TDF exposure. BP = blood pressure; eGFR = estimated glomerular filtration rate (CKD-EPI); LDL = low-density lipoprotein; HDL = high-density lipoprotein; TG = triglycerides; CVD = cardiovascular disease; BMI = body mass index; circ = circumference; ART = antiretroviral therapy.