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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: J Allergy Clin Immunol. 2018 Jun 20;143(1):258–265. doi: 10.1016/j.jaci.2018.06.012

FIG 3. Asymmetric enlarged germinal centers (GCs) predominate in lymph nodes from CVID+AIC patients.

FIG 3.

(A) Hematoxylin- and eosin-stained axillary lymph node biopsies from a representative immunocompetent 43-year-old female (Control), two CVID-AIC patients, and three CVID+AIC patients. GCs are outlined with white dashed lines. Original magnification, 12.5X. (B) The percentages of each lymph node’s cellular two-dimensional surface comprised by GCs and (C) each GCs circularity quotient are represented for controls and patients. Statistically significant differences are indicated: ****P <0.0001, **P <0.01 (Mann-Whitney U tests).